Home

The results of the Danish observational cohort study, published in the European Heart Journal – Cardiovascular Pharmacotherapy, showed that rates of thromboembolism—ischaemic stroke and systemic embolism—were similar to those observed in the composite ‘stroke’ outcome in the ENGAGE AF-TIMI 48 clinical trial, a study comparing the long-term efficacy and safety of Lixiana with warfarin in AF patients.

In addition, primary (composite) bleeding outcomes requiring hospitalisation were approximately 50% lower than observed in ENGAGE AF-TIMI 48. The real-world findings reinforce Lixiana’s efficacy and safety profile in elderly AF patients in routine clinical practice, Daiichi Sankyo said in a press release.

Many patients were elderly with comorbidities and almost one-fourth (23.5%) had a hospital diagnosis of cancer.

Commenting on the study, lead author, Peter Brønnum Nielsen (Aalborg Thrombosis Research Unit, Aalborg University, Denmark), said: “These new data, reporting on outcomes in a European AF population seen in routine clinical practice, are reassuring as they reinforce previous evidence that edoxaban has a good safety profile and is an effective treatment for the prevention of stroke in a broad AF population.”

643 patients (28%) received Lixiana 30 mg dosage regimen and 1,642 (72%) Lixiana 60 mg which is similar to the split in ENGAGE AF-TIMI 48. The primary effectiveness endpoint of thromboembolism, comprised of a composite outcome of stroke and systemic embolism, occurred 41 times. In patients taking Lixiana 30 mg daily (dose reduced) the event rate was 2.07 per 100 person-years, and in those taking Lixiana 60 mg daily (full dose) the event rate was 1.62 per 100 person-years.

The safety outcomes, comprised of a composite of all bleedings, including intracranial, gastrointestinal and major bleeding in other anatomic sites, occurred 89 times. Safety outcome event rates were similar among the full dose and dose reduced groups, with rates of 3.87 and 3.85 per 100 person-years respectively.

Gastrointestinal bleeding occurred <10 times and intracranial bleeding occurred <12 times among the total cohort. The remaining bleeds (74 major) were in other anatomical locations. In addition, 40 of the total bleeds required hospitalisation (1.74 per 100 person-years in the dose reduced group and 1.69 in the full dose group).

“Real-world data, such as these, provide us with a greater understanding of AF treatment pathways and broaden our insight into the patient population,” said Wolfgang Zierhut, MD, executive director medical affairs and Head Thrombosis and Cardiovascular at Daiichi Sankyo Europe. “We are committed to adding to the growing body of evidence on the use of edoxaban through real-world data, particularly in the underserved elderly population.”

Source CardiovascularNews

Duc Tin Clinic

Tin tức liên quan

Enrolment reaches midway point in trial of Early Bird bleed monitoring system

Eight-fold increased risk of heart attack seen in patients with subclinical obstructive coronary atherosclerosis

ACC 2023: REVIVED-BCIS-2 results challenge “long-held beliefs” on myocardial viability testing prior to PCI

Blood pressure successfully cut in RADIANCE II ultrasound renal denervation trial

New data examine mortality rates and cardiac damage in early-stage aortic stenosis patients

SUPPORT CONSULTANT

Make an Appointment

I am Nguyen Thanh Sang, born in 1990. Since the examination and treatment at the clinic Duc Tin, I am very grateful to the Doctor for explaining and sharing about my illness. During the treatment time in the clinic I was very caring staff of the clinic. Now my illness has improved in a good way. Expect more and more clinic to be able to save many patients.

I sincerely thank you !. Tel: 0938303275

Huynh Thi Muoi, born in 1940, was examined and treated at Duc Tin Clinic. I am very pleased about how to serve and care patients of the clinic. The doctor is committed to explaining and sharing with the patient.

Huynh Thi Muoi sincerely thank you! Phone number: 0972868746

As I said Duc Tin surgical clinin is where my family trust, hope to visit. Physicians caring, thoughtful, gentle to the patient. Nurses and staff clinic polite, cheerful and thoughtful. This clinic clean, sterile, so I would love to. Tel: +84949914060.

The doctor is very caring, attentive and very gentle nurse, courteous, affable with me. The clinic is clean, comfortable, polite. I enjoyed this faith. Every visit I was very relieved disease. Tel: 0839820792.

I was patient, had to clinics of Dr. Le Duc Tin. I see very conscientious doctor patient care, answer any questions and very dedicated staff from the receptionist to the children tested, nursing. Clinics very clean and spacious. I'm very satisfied. Tel: +841227880829.