Hotline 24/7: 0909384389

Share links:

Raised troponin and interleukin-6 levels are associated with a poor prognosis in COVID-19

Ngày 03/04/2020 09:10 | Lượt xem: 1214

A raised troponin level in myocardial injury “greatly alters the prognosis adversely” in COVID-19 patients, Graham Cole (Imperial College Healthcare NHS Trust, London, UK) told a virtual cardiovascular conference, hosted today by Imperial College London.

Cole explained: “Troponin rises occur in the context of lots of other abnormalities, and can partition patients into those who survive and those who do not ”

He was speaking as part of a session on the science behind COVID-19 and cardiovascular disease, and therapeutic possibilities.

Citing data from Wuhan in China, Cole said that mortality was 50% among cases who troponin levels were increased, while only 1% of those who survive have raised levels.

“Myocardial injury is key in COVID-19; I do not  know the exact mechanism but I know it is very important.” He explained that the myocardial injury seen with COVID-19 does not follow the usual pattern: “Age and risk factors are not the same as they are in typical myocarditis. Patients are older and it is associated with cardiovascular risk factors. I think that indicates that there is a different mechanism.”

Referring to the single case report that has been published with cardiac imaging of scar injury, he described it as “difficult to interpret”, adding, “I have not seen a myocarditis pattern like this before”.

Source CardiovascularNews

Duc Tin clinic

Cole speculated that ACE-2 receptors may be important, but said the mechanism of action remains unclear and “may well be multifactorial”. He also queried whether thrombosis has relevance.

Other presentations in the same session dealt with the immunopathogenesis of COVID-19 (Peter Openshaw, Imperial College), the risk of vascular complications in COVID-19 (Joe Boyle, Imperial College), and novel technologies for investigating COVID-19 and the cardiovascular system (Amir Lerman, Mayo Clinic, Rochester, USA).

In addition, three talks addressed potential therapies. Justin Mason (National Heart and Lung Institute, Imperial College) looked at hydroxychloroquine: “As yet,” he said, “there is little evidence for it, but it has intriguing aspects.” It is currently being used in most of the treatment protocols in China, Italy, France and South Korea.

Dorian Haskard (Imperial College) said that clinical trials for colchicine were “justified”. “Although there is currently no data for its use, it is worthy of consideration, especially in patients with vascular comorbidities.”

Taryn Youngstein (Imperial College) covered the possibilities for anti-interleukin (IL)-6 therapy. She told the online audience that its potential is based on the fact that IL-6 is responsible for a large part of the acute-phase response. As with troponin, high levels of IL-6 are associated with a poor prognosis in COVID-19.

Tin tức liên quan

Enrolment reaches midway point in trial of Early Bird bleed monitoring system

Eight-fold increased risk of heart attack seen in patients with subclinical obstructive coronary atherosclerosis

ACC 2023: REVIVED-BCIS-2 results challenge “long-held beliefs” on myocardial viability testing prior to PCI

Blood pressure successfully cut in RADIANCE II ultrasound renal denervation trial

New data examine mortality rates and cardiac damage in early-stage aortic stenosis patients

SUPPORT CONSULTANT

CUSTOMER REVIEWS

• I am Nguyen Thanh Sang, born in 1990. Since the examination and treatment at the clinic Duc Tin, I am very grateful to the Doctor for explaining and sharing about my illness. During the treatment time in the clinic I was very caring staff of the clinic. Now my illness has improved in a good way. Expect more and more clinic to be able to save many patients.

  I sincerely thank you !. Tel: 0938303275

• Huynh Thi Muoi, born in 1940, was examined and treated at Duc Tin Clinic. I am very pleased about how to serve and care patients of the clinic. The doctor is committed to explaining and sharing with the patient.

  Huynh Thi Muoi sincerely thank you! Phone number: 0972868746

• As I said Duc Tin surgical clinin is where my family trust, hope to visit. Physicians caring, thoughtful, gentle to the patient. Nurses and staff clinic polite, cheerful and thoughtful. This clinic clean, sterile, so I would love to. Tel: +84949914060.

• The doctor is very caring, attentive and very gentle nurse, courteous, affable with me. The clinic is clean, comfortable, polite. I enjoyed this faith. Every visit I was very relieved disease. Tel: 0839820792.

• I was patient, had to clinics of Dr. Le Duc Tin. I see very conscientious doctor patient care, answer any questions and very dedicated staff from the receptionist to the children tested, nursing. Clinics very clean and spacious. I'm very satisfied. Tel: +841227880829.

Search

News

Customer support